Síndrome de hipersensibilidad a anticomiciales: una entidad para recordar / Anticonvulsant hypersensitivity syndrome: An entity to be remembered

El síndrome de hipersensibilidad a anticomiciales es una reacción adversa grave e impredecible, inicialmente descrita con antiepilépticos aromáticos, como la carbamacepina, la fenitoína y el fenobarbital. Suele caracterizarse por presencia de fiebre, eosinofilia, erupción cutánea y afectación de uno o más órganos internos. No existen criterios diagnósticos ni normas de tratamiento claramente establecidos. Es necesario un alto índice de sospecha para identificar esta entidad como un verdadero síndrome, suspender precozmente el fármaco implicado y evitar nuevas exposiciones. A continuación comunicamos un ilustrativo caso clínico y revisamos la literatura médica publicada (AU)

Anticonvulsant hypersensitivity syndrome is an unpredictable, potentially fatal drug reaction to aromatic anticonvulsants such as carbamazepine, phenytoin and phenobarbital. The hallmark features include fever, eosinophilia, rash and involvement of one or more internal organs. Clearly established diagnostic criteria and treatment guidelines are lacking. A high index of suspicion is required to identify this syndrome, allowing early withdrawal of the drug and avoiding re-exposure. We report an illustrative case of anticonvulsant hypersensitivity syndrome and review the published literature (AU)

[Anticonvulsant hypersensitivity syndrome: an entity to be remembered]. / Síndrome de hipersensibilidad a anticomiciales: una entidad para recordar.

Anticonvulsant hypersensitivity syndrome is an unpredictable, potentially fatal drug reaction to aromatic anticonvulsants such as carbamazepine, phenytoin and phenobarbital. The hallmark features include fever, eosinophilia, rash and involvement of one or more internal organs. Clearly established diagnostic criteria and treatment guidelines are lacking. A high index of suspicion is required to identify this syndrome, allowing early withdrawal of the drug and avoiding re-exposure. We report an illustrative case of anticonvulsant hypersensitivity syndrome and review the published literature.

Una causa infrecuente de obstrucción gástrica: síndrome de Bouveret / An uncommon cause of gastric outlet obstruction: Bouveret's syndrome

El síndrome de Bouveret (SB) es un tipo infrecuente de íleo biliar consistente en una obstrucción gastroduodenal secundaria al paso de cálculos desde la vesícula biliar al duodeno, a través de una fístula colecisto o coledocogastroduodenal. La primera descripción de este síndrome la realizó en 1896 León Bouveret. Desde esta época se han descrito en la literatura médica poco más de 200 casos. Si bien la mortalidad del cuadro se establece en un 25%, el pronóstico viene determinado por la comorbilidad, la edad avanzada y el retraso en el diagnóstico. Para llegar al diagnóstico suelen precisarse tanto técnicas radiológicas (radiografía simple, ecografía, tomografía computarizada o resonancia magnética) como endoscópicas. Se debe intentar siempre el tratamiento endoscópico, aunque es muy frecuente que éste sea fallido y sea preciso recurrir al tratamiento quirúrgico. Presentamos el caso de un paciente que consultó por la aparición de vómitos pospandriales y epigastralgia. A continuación discutimos el manejo diagnóstico y terapéutico de esta infrecuente causa de obstrucción gástrica

Bouveret’s syndrome is a rare type of gallstone ileus inwhich a gallstone enters the intestinal tract via a cholecystoenteric fistula and is lodged in the duodenum or the stomach. Since the first description by León Bouveret in 1896, fewer than 200 cases have been described in the worldwide literature. Mortality is high, at 25%, but may be related to the advanced age of the typical patient and comorbidities, aswell as diagnostic delay. Diagnosis may be made with radiological (abdominal X-ray, ultrasound, computed tomography or magnetic resonance imaging) and endoscopictechniques. Endoscopy is preferred as the first therapeutic option but is frequently unsuccessful and surgery is often required. We present the case of a patient admitted to hospital with a history of vomiting after eating and epigastric pain. The management of this rare cause of gastric outlet obstruction is discussed (AU)

[A rare cause of gastric outlet obstruction: Bouveret's syndrome]. / Una causa infrecuente de obstrucción gástrica: síndrome de Bouveret.

Bouveret's syndrome is a rare type of gallstone ileus in which a gallstone enters the intestinal tract via a cholecystoenteric fistula and is lodged in the duodenum or the stomach. Since the first description by León Bouveret in 1896, fewer than 200 cases have been described in the worldwide literature. Mortality is high, at 25%, but may be related to the advanced age of the typical patient and comorbidities, as well as diagnostic delay. Diagnosis may be made with radiological (abdominal X-ray, ultrasound, computed tomography or magnetic resonance imaging) and endoscopic techniques. Endoscopy is preferred as the first therapeutic option but is frequently unsuccessful and surgery is often required. We present the case of a patient admitted to hospital with a history of vomiting after eating and epigastric pain. The management of this rare cause of gastric outlet obstruction is discussed.

[Filgrastim in refractory Crohn's disease with an intra-abdominal abscess]. / Filgrastim en la enfermedad de Crohn refractaria con absceso intraabdominal.

The application of recombinant human granulocyte colony-stimulating factor (filgrastim) seems to be a safe, well tolerated and potentially effective therapy for active Crohn's disease. We report the case of an adolescent boy with Crohn's disease and intra-abdominal abscess associated who had a significant response to treatment with recombinant human granulocyte colony-stimulating factor after all standard treatments had failed.

[Pain originating from the abdominal wall: a forgotten diagnostic option]. / Dolor originado en la pared abdominal: una alternativa diagnóstica olvidada.

Chronic abdominal pain is a common clinical problem in primary care, and is usually referred to gastroenterologists or general surgeons. Although up to 20% of cases of idiopathic abdominal pain arise in structures of the abdominal wall, this is frequently overlooked as a possible cause. It includes pain arising from structures of the abdominal wall including skin, parietal peritoneum, cellular subcutaneous tissue, aponeuroses, abdominal muscles and somatosensorial innervation from lower dorsal roots. The diagnosis is based on anamnesis and physical examination. Carnett's sign is a simple maneuver that discriminates between parietal and visceral pain. Management with topical anesthesia is effective in a majority of patients and can help to confirm the diagnosis.

Filgrastim en la enfermedad de Crohn refractaria con absceso intraabdominal / Filgrastim in refractory Crohn’s disease with an intra-abdominal abscess

El tratamiento con factor recombinante estimulante de progenitores granulocíticos (filgrastim) parece ser una alternativa terapéutica segura, bien tolerada y potencialmente efectiva en pacientes con una enfermedad de Crohn activa. Presentamos el caso de un varón adolescente con enfermedad de Crohn y absceso intraabdominal asociado, en el que los tratamientos convencionales habían fracasado, que experimentó una importante respuesta al tratamiento con factor recombinante estimulante de progenitores granulocíticos

The aplication of recombinant human granulocyte colony-stimulating factor (filgrastim) seems to be a safe, well tolerated and potentially effective therapy for active Crohn's disease. We report the case of an adolescent boy with Crohn's disease and intra-abdominal abscess associated who had a significant response to treatment with recombinant human granulocyte colony-stimulating factor after all standard treat-ments had failed

Dolor originado en la pared abdominal: una alternativa diagnóstica olvidada / Pain originating from the abdominal wall: a forgotten diagnostic option

El dolor abdominal crónico es un problema clínico muy frecuente abordado en atención primaria, habitualmente remitido a los especialistas de gastroenterología y cirugía general. A pesar de que, según los estudios publicados, hasta un 20% de los pacientes estudiados por dolor abdominal crónico no filiado se corresponden con una enfermedad de la pared abdominal, pocos médicos plantean esta entidad dentro del diagnóstico diferencial. Incluye todas las enfermedades originadas en estructuras de la pared abdominal: piel, peritoneo parietal, tejido celular subcutáneo, aponeurosis y grupos musculares abdominales e inervación somatosensorial de las raíces nerviosas T7 a T12. Su diagnóstico se basa en la historia clínica y la exploración física. El signo de Carnett es una maniobra exploratoria sencilla que discrimina entre enfermedad visceral y de la pared. El tratamiento con anestésicos tópicos es efectivo en la mayoría de los pacientes y puede ayudar a confirmar el diagnóstico de sospe

Chronic abdominal pain is a common clinical problem in primary care, and is usually referred to gastroenterologists or general surgeons. Although up to 20% of cases of idiopathic abdominal pain arise in structures of the abdominal wall, this is frequently overlooked as a possible cause. It includes pain arising from structures of the abdominal wall including skin, parietal peritoneum, cellular subcutaneous tissue, aponeuroses, abdominal muscles and somatosensorial innervation from lower dorsal roots. The diagnosis is based on anamnesis and physical examination. Carnett's sign is a simple maneuver that discriminates between parietal and visceral pain. Management with topical anesthesia is effective in a majority of patients and can help to confirm the diagnosis